Novel hit of DPP-4Is as promising antihyperglycemic agents with dual antioxidant/anti-inflammatory effects for type 2 diabetes with/without COVID-19Research article Published on 2022-11-012022-10-05 Journal: Bioorganic chemistry [Category] SARS, 신약개발, [키워드] activities activity addition Anti-inflammatory antioxidant Cell Co-receptor consequence COVID-19 CRP derivatives DPPH Effect evaluated IL-6 infections molecular docking not correlated novel OGT Patient Pyrimidinones question raised SARS-CoV-2 screened small molecule drug tested therapy Treatment type 2 diabete type 2 diabetes [DOI] 10.1016/j.bioorg.2022.106092 [Article Type] Research article
A lipid nanoparticle platform for mRNA delivery through repurposing of cationic amphiphilic drugsResearch article Published on 2022-10-012022-10-05 Journal: Journal of controlled release : official journal o [Category] 신약개발, [키워드] addition approach approval bovine CAD cancer cell cationic Cationic amphiphilic drugs Cationic lipid Cell Cellular delivery component Corneal COVID-19 mRNA vaccines drug drug combination Drug repurposing Efficiency encapsulation epithelial cell epithelial cells eyes functional healthcare HeLa cell in vitro in vivo Lipid lipid component Lipid nanoparticles Liposome LNP maintain Messenger RNA mRNA nanomedicine Patient pharmacological platform primary cell RNA RNA therapeutics selected small molecule drug subsequent Therapies Vesicle was obtained [DOI] 10.1016/j.jconrel.2022.08.009 [Article Type] Research article
Beyond the vaccines: a glance at the small molecule and peptide-based anti-COVID19 arsenalReview Published on 2022-09-062022-10-04 Journal: Journal of Biomedical Science [Category] SARS, 변종, 신약개발, [키워드] 3CLpro 3CLpro inhibitors accelerated ACE-2 ACE2 antibody anticipated Antiviral effect approach benefit composed Conjugates conserved Coronaviruses COVID-19 COVID-19 pandemic COVID19 drug Drug discovery effort Evidence FDA approval In-vitro inhibitor Medicinal chemistry monoclonal antibodies peptide-based peptides plethora PLPro PLpro inhibitors Predictive model Prevent Proteases Protein pursuit RdRP RdRp inhibitors Replication reported required researcher S protein SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 variant SARS-CoV-2 variants small molecule small molecule drug Small molecule inhibitors targets therapeutic option TMPRSS2 TMPRSS2 drug repurposing TMPRSS2 inhibitors Treatment vaccination vaccine platform Vaccines viral entry viral replication viral replication. [DOI] 10.1186/s12929-022-00847-6 PMC 바로가기 [Article Type] Review
SARS-CoV-2 and the NucleusSARS-CoV-2와 핵Review Published on 2022-07-112022-09-11 Journal: International Journal of Biological Sciences [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] blocked caused cells cilia Clinical studies contribute COVID-19 pandemic Critical cytoplasm DNA DNA damage Epigenetic epigenetics Genome greatly reduce immune responses inhibitor innate immune responses Innate immunity lack life cycle mechanisms metabolism mRNA metabolism nuclear nuclear translocation nuclear transport. nucleus other coronavirus other coronaviruses pathway Pathways pharmacological Regulation replicated RNA virus rupture SARS-CoV-2 small molecule small molecule drug small molecule drugs Therapeutic treatment Transport virus infection virus replication [DOI] 10.7150/ijbs.72482 PMC 바로가기 [Article Type] Review
Broad-spectrum CRISPR-mediated inhibition of SARS-CoV-2 variants and endemic coronaviruses in vitroArticle Published on 2022-05-192022-10-04 Journal: Nature Communications [Category] COVID19(2023년), SARS, 변종, 진단, 치료제, [키워드] Air-liquid interface airway epithelium Antiviral Antiviral effect Antiviral treatment BSA can be used cellular Combination complementary coronavirus coronavirus coronavirus strain CRISPR-Cas systems cultures dependent on Endemic ENhance human coronaviruses human primary cells in vitro Infection inhibit magnitude mutations new SARS-CoV-2 offer omicron Prophylaxis reduced reduction RNA SARS-CoV-2 SARS-CoV-2 variant significantly small molecule drug Synthetic biology therapeutic effect treat Treatment vaccination variant variants viral evolution Viral RNA viral titer [DOI] 10.1038/s41467-022-30546-7 PMC 바로가기 [Article Type] Article
In silico analysis of SARS-CoV-2 proteins as targets for clinically available drugs임상적으로 이용 가능한 약물의 표적으로서 SARS-CoV-2 단백질의 in silico 분석Article Published on 2022-03-292022-09-11 Journal: Scientific Reports [Category] Coronavirus, SARS, 신약개발, 치료법, 치료제, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Amprenavir Analysis avanafil binding binding site calcipotriol caused cells clinically Compound coronavirus develop disease docked docking domain Domperidone drug FDA-approved drug FDA-approved drugs filtered framework had no Huh-7 human liver identify in vitro involved levomefolic acid Mac1 moderate molecular dynamics Molecular dynamics simulation molecular dynamics simulations Nintedanib non-structural protein NSP Nsp15 nucleocapsid protein pandemic predicted provide reported SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 protein SARS-CoV-2 proteins severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs Spike protein target target proteins targets the spike protein Treatment Viral RNA Virtual screening [DOI] 10.1038/s41598-022-08320-y PMC 바로가기 [Article Type] Article
RdRp inhibitors and COVID-19: Is molnupiravir a good option?Review Published on 2021-12-092023-06-14 Journal: Biomedicine & pharmacotherapy = Biomédecine & phar [Category] MERS, [키워드] clinical trials RdRp inhibitors, Molnupiravir SARS-CoV-2 small molecule drug [DOI] 10.1016/j.biopha.2021.112517 PMC 바로가기 [Article Type] Review
In silico binding profile characterization of SARS-CoV-2 spike protein and its mutants bound to human ACE2 receptorSARS-CoV-2 스파이크 단백질 및 인간 ACE2 수용체에 결합된 돌연변이체의 인 실리코(in silico) 결합 프로필 특성화Article Published on 2021-11-052022-09-11 Journal: Briefings in Bioinformatics [Category] MERS, SARS, 변종, 진단, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus affected approach binding binding affinities binding affinity binding free energies binding free energy complexes Complexes coronavirus country COVID-19 decomposition domain drug resistance free energies free energy Free energy calculation and decomposition Free energy calculations G476S hACE2 hACE2 protein hotspot Hotspot residues human ACE2 human ACE2 receptor infect interfere investigated MD simulation molecular molecular dynamics Molecular mechanics mutant nine Novel coronavirus pandemic Poisson Protein–protein interaction protocol prototype provide RBD RBD mutations RBDs receptor Receptor-binding domain respiratory SARS-CoV-2 SARS-CoV-2 spike protein SARS-CoV-2 Spike RBD severe acute respiratory syndrome Coronavirus small molecule small molecule drug small molecule drugs spike spike glycoprotein Spike RBD/hACE2. Structure structures surface area V367F V483A Vaccine virus [DOI] 10.1093/bib/bbab188 PMC 바로가기 [Article Type] Article
Drugs in COVID-19 Clinical Trials: Predicting Transporter-Mediated Drug-Drug Interactions Using In Vitro Assays and Real-World DataCOVID-19 임상 시험의 약물: 체외 분석 및 실제 데이터를 사용하여 운반체 매개 약물-약물 상호작용 예측Article Published on 2021-07-012022-09-11 Journal: Clinical Pharmacology and Therapeutics [Category] SARS, 임상, 치료제, [키워드] accelerated ADRS Adverse drug reaction Adverse drug reactions Chloroquine clinical clinical investigation clinical study clinical trial clinical trials clinically concentrations concomitant medications coronavirus disease Coronavirus disease 2019 COVID-19 criteria database determine drug drug-drug interaction Efficacy Electronic health records expressing Future HEK293 cell HEK293 cells Hydroxychloroquine inhibit membrane vesicle Numerous Older patients with COVID-19 predict predicted real-world data Regulatory Authorities regulatory authority representing risk Risk assessment Sildenafil small molecule small molecule drug target targets Treatment [DOI] 10.1002/cpt.2236 PMC 바로가기 [Article Type] Article
The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19중증 COVID19 관리를 위한 코르티코스테로이드 요법에서 비-게놈 표적으로서 인간 C5a의 역할Article Published on 2021-06-012022-09-12 Journal: Computational biology and chemistry [Category] MERS, SARS, 신약개발, 진단, [키워드] activate acute respiratory syndrome amplified appear binding C3a C5a chemoattractant Circular Circular dichroism clinical evidence Colchicine combination therapy complement complement system contribute Coronavirus-2 corticosteroid therapy Corticosteroids COVID19 Cytokine storm Dexamethasone drug Effect Fluorescence globe Host immunomodulator indicate Inflammatory management moderate modulating molecular dynamics morbidity and mortality Neutralizing non-genomic non-specific pathophysiological Pathways physiological Polypharmacology positive Prednisone Prednisone. probe Prophylactic PROTECT reducing repurposing Safe SARS-CoV2 severity Signaling significantly small molecule drug triggered triggering Vaccine while [DOI] 10.1016/j.compbiolchem.2021.107482 PMC 바로가기 [Article Type] Article